Acute effect of smoking on plasma Obestatin levels
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Department of Endocrinology, Medical School Democritus University of Thrace, Alexandroupolis, Greece
Department of Pneumonology, Medical School Democritus University of Thrace, Alexandroupolis, Greece
1st Department of Pneumonology, GH "G Papanikolaou", Thessaloniki, Greece
Department of Nuclear Medicine, Medical School University of Crete, Heraklion, Greece
Stavros Tryfon Tryfon   

1st Department of Pneumonology, GH “G Papanikolaou”, Thessaloniki, Greece
Submission date: 2009-04-27
Acceptance date: 2010-01-07
Publication date: 2010-01-07
Tobacco Induced Diseases 2010;8(January):2
Smoking and smoking cessation are considered to be associated with weight changes. We have recently shown that smoking acutely increases plasma levels of ghrelin, a known orexigenic hormone. Obestatin is a peptide encoded by the ghrelin gene, which opposes ghrelin effects on food intake. We conducted a study in adult volunteers measuring plasma levels of obestatin immediately after initiation of smoking.

31 volunteers (mean age 32.2 ± 9.2 years and mean BMI 25.7 ± 4.1), 17 smokers and 14 non-smokers, were enrolled in our study. The 2 groups were matched in age and BMI. Plasma obestatin concentrations were determined at baseline (T0), 2 (T2), 5 (T5), 15 (T15), and 60 (T60) minutes after the initiation of smoking.

In all 31 subjects, no significant difference in the mean values of plasma obestatin levels was observed from baseline at T2, T5, T15 and T60 after initiation of smoking (overall p = 0.15). However, a trend for higher obestatin levels was noted in smokers vs non-smokers (overall p = 0.069), which was not related to the pack-years.

On the contrary with ghrelin's response after smoking initiation, there is no such an acute response of plasma obestatin levels.

Filozof C, Fernandez Pinilla MC, Fernandez-Cruz A: Smoking cessation and weight gain. Obes Rev. 2004, 5 (2): 95-103. 10.1111/j.1467-789X.2004.00131.x.
Cryer PE, Haymond MW, Santiago JV, Shah SD: Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events. N Engl J Med. 1976, 295 (11): 573-7.
Bouros D, Tzouvelekis A, Anevlavis A, Doris M, Tryfon S, Froudarakis M, Zournatzi V, Kukuvitis A: Smoking acutely increases plasma ghrelin concentrations. Clin Chem. 2006, 52 (4): 777-8. 10.1373/clinchem.2005.065243.
Gualillo O, Lago F, Casanueva FF, Dieguez C: One ancestor, several peptides post-translational modifications of preproghrelin generate several peptides with antithetical effects. Mol Cell Endocrinol. 2006, 256 (1-2): 1-8. 10.1016/j.mce.2006.05.007.
Gourcerol G, St-Pierre DH, Tache Y: Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)?. Regul Pept. 2007, 141 (1-3): 1-7. 10.1016/j.regpep.2006.12.023.
Yamamoto D, Ikeshita N, Daito R, Herningtyas EH, Toda K, Takahashi K, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y: Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats. Regul Pept. 2007, 138 (2-3): 141-4. 10.1016/j.regpep.2006.09.001.
Garg A: The ongoing saga of obestatin: is it a hormone?. J Clin Endocrinol Metab. 2007, 92 (9): 3396-8. 10.1210/jc.2007-0999.
Guo ZF, Zheng X, Qin YW, Hu JQ, Chen SP, Zhang Z: Circulating preprandial ghrelin to obestatin ratio is increased in human obesity. J Clin Endocrinol Metab. 2007, 92 (5): 1875-80. 10.1210/jc.2006-2306.
Lee H, Joe KH, Kim W, Park J, Lee DH, Sung KW, Kim DJ: Increased leptin and decreased ghrelin level after smoking cessation. Neurosci Lett. 2006, 409 (1): 47-51. 10.1016/j.neulet.2006.09.013.
Zizzari P, Longchamps R, Epelbaum J, Bluet-Pajot MT: Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents. Endocrinology. 2007, 148 (4): 1648-53. 10.1210/en.2006-1231.
Park WH, Oh YJ, Kim GY, Kim SE, Paik KH, Han SJ, Kim AH, Chu SH, Kwon EK, Kim SW, Jin DK: Obestatin is not elevated or correlated with insulin in children with Prader-Willi syndrome. J Clin Endocrinol Metab. 2007, 92 (1): 229-34. 10.1210/jc.2006-0754.
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