Tobacco use increases susceptibility to bacterial infection
Donald R Demuth 1, 2
David A Scott 1, 3, 2  
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Department of Microbiology and Immunology, University of Louisville, Louisville, USA
Oral Health and Systemic Disease Research Group, University of Louisville, Louisville, USA
Department of Pharmacology and Toxicology, University of Louisville, Louisville, USA
Publish date: 2008-12-18
Tobacco Induced Diseases 2008;4(December):12
Active smokers and those exposed to secondhand smoke are at increased risk of bacterial infection. Tobacco smoke exposure increases susceptibility to respiratory tract infections, including tuberculosis, pneumonia and Legionnaires disease; bacterial vaginosis and sexually transmitted diseases, such as chlamydia and gonorrhoea; Helicobacter pylori infection; periodontitis; meningitis; otitis media; and post-surgical and nosocomial infections. Tobacco smoke compromises the anti-bacterial function of leukocytes, including neutrophils, monocytes, T cells and B cells, providing a mechanistic explanation for increased infection risk. Further epidemiological, clinical and mechanistic research into this important area is warranted.
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American Journal of Physiology-Lung Cellular and Molecular Physiology
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Alimentary Pharmacology & Therapeutics
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