Harmful effects from one puff of shisha-pen vapor: methodological and interpretational problems in the risk assessment analysis
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Department of Cardiology, Onassis Cardiac Surgery Center, Kallithea, Greece
Department of Pharmacy, University of Patras, Rio, Greece
Faculty of Psychology and Educational Sciences, KU Leuven-University of Leuven, Leuven, Belgium
Submission date: 2015-07-08
Acceptance date: 2016-06-06
Publication date: 2016-07-07
Corresponding author
Konstantinos E. Farsalinos   

Department of Cardiology, Onassis Cardiac Surgery Center, Sygrou 356, Kallithea 17674, Greece
Tobacco Induced Diseases 2016;14(July):22
With this letter we express our concerns about the applicability of the proposed Margin of Exposure analysis as a method of risk assessment for propylene glycol and glycerol exposure from a shisha-pen type electronic cigarette. The studies used to determine the Margin of Exposure were evaluating the effects in humans or animals of continuous exposure to these chemicals in every single breath, whereas electronic cigarettes are used intermittently by consumers, resulting in lower and discontinuous exposure. Moreover, the authors make no clear distinction between irritation and harm, neither do they discuss the effects of exposure compared to continuous smoking.
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Analytical Assessment of E-Cigarettes
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Konstantinos Farsalinos
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