Effect of tobacco on periodontal disease and oral cancer
Yixin Zhang 1
Jinxiu He 1
Bing He 2
Ruijie Huang# 1
Mingyun Li# 1  
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State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China
Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, United States
Ruijie Huang#
State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China
Mingyun Li#   

State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China
Publish date: 2019-05-09
Tob. Induc. Dis. 2019;17(May):40
#Co-correspondence authors
Periodontal disease and oral cancer are common health hazards. Epidemiological investigations show that smoking, periodontal disease and oral cancer are closely related. Tobacco is one of the major risk factors for periodontitis and oral cancer.

A systematic literature review was performed. To identify relevant studies, the following online databases were searched using specific keywords: PubMed, Web of Science and CNKI.

Tobacco not only possesses an addictive effect, but it aggravates periodontal disease by promoting the invasion of pathogenic bacteria, inhibiting autoimmune defense, aggravating the inflammatory reaction, and aggravating the loss of alveolar bone. According to current evidence, tobacco significantly aggravates the development and progression of periodontal disease and oral cancer, and periodontal disease may be related to the prevalence of oral cancer.

Clinicians should strongly recommend that smokers undertake a strategy to stop smoking to avoid the exacerbation of nicotine-related periodontal disease and to reduce the incidence of oral cancer.

Authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none was reported.
This review was supported by the National Natural Science Foundation of China (81400501 to ML, 31800114 to RH and 81500811 to BH).
YZ, RH and ML contributed to the design, drafting and revision of the review. JH and BH contributed to the revision of the review.
Not commissioned; externally peer reviewed.
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