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RESEARCH PAPER
Associations of cigarette use, e-cigarette use, and dual use, with nocturia and urge urinary incontinence in US adults
1
Department of Urology,
Kidney and Urology Center,
Pelvic Floor Disorders Center,
The Seventh Affiliated
Hospital, Sun Yat-sen
University, Shenzhen, China
2
Guangming District Health
Bureau, Shenzhen, China
3
The Nethersole School of
Nursing, Faculty of Medicine,
The Chinese University of
Hong Kong, Hong Kong SAR,
China
These authors had equal contribution to this work
Submission date: 2024-11-01
Final revision date: 2025-02-11
Acceptance date: 2025-02-14
Publication date: 2025-03-07
Corresponding author
Jun Pang
Department of Urology, Kidney and Urology Center, Pelvic Floor Disorders Center, The Seventh Affiliated Hospital, Sun Yat-sen University, No.628 Zhenyuan Road, Shenzhen, 518107, China
Department of Urology, Kidney and Urology Center, Pelvic Floor Disorders Center, The Seventh Affiliated Hospital, Sun Yat-sen University, No.628 Zhenyuan Road, Shenzhen, 518107, China
Tob. Induc. Dis. 2025;23(March):25
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Associations of cigarette use, e-cigarette use, and dual use, with nocturia and urge urinary incontinence (UUI) remain unclear. We performed this study to investigate the associations of cigarette use, e-cigarette use, and dual use, with nocturia and UUI.
Methods:
This is a secondary analysis using data from the 2005 to 2020 National Health and Nutrition Examination Survey (NHANES). Participants aged ≥20 years were included. The use of cigarettes and e-cigarettes and symptoms of nocturia and UUI were self-reported. Logistic regression was used to calculate the adjusted odd ratios (AORs) of nocturia and UUI for cigarette use, e-cigarette use, and dual use. Subgroup analyses were conducted among participants with prostate cancer.
Results:
Compared to never cigarette users, current and former cigarette users had higher odds of nocturia (AOR=1.12; 95% CI: 1.02–1.23; AOR=1.12; 95% CI: 1.01–1.24; all p<0.05) and UUI (AOR=1.23; 95% CI: 1.09–1.39; AOR=1.13; 95% CI: 1.03–1.24; all p<0.01). Compared to never e-cigarette users, current e-cigarette users had higher odds of nocturia (AOR=1.43; 95% CI: 1.01–2.02; p<0.05) and UUI (AOR=1.56; 95% CI: 1.13–2.16; p<0.01) and former e-cigarette users had higher odds of UUI (AOR=1.29; 95% CI: 1.02–1.62; p<0.05). Dual users of cigarettes and e-cigarettes had higher odds of nocturia (AOR=1.61; 95% CI: 1.03–2.51; p<0.05) and UUI (AOR=1.79; 95% CI: 1.19–2.68; p<0.01) compared to never users. In participants with prostate cancer, current cigarette use was associated with higher odds of UUI (AOR=2.40; 95% CI: 1.04–5.57; p<0.05.
Conclusions:
This study found that cigarette use, e-cigarette use, and dual use were associated with higher odds of nocturia and UUI. Cohort studies are needed to determine the causality of this cross-sectional assessment.
Associations of cigarette use, e-cigarette use, and dual use, with nocturia and urge urinary incontinence (UUI) remain unclear. We performed this study to investigate the associations of cigarette use, e-cigarette use, and dual use, with nocturia and UUI.
Methods:
This is a secondary analysis using data from the 2005 to 2020 National Health and Nutrition Examination Survey (NHANES). Participants aged ≥20 years were included. The use of cigarettes and e-cigarettes and symptoms of nocturia and UUI were self-reported. Logistic regression was used to calculate the adjusted odd ratios (AORs) of nocturia and UUI for cigarette use, e-cigarette use, and dual use. Subgroup analyses were conducted among participants with prostate cancer.
Results:
Compared to never cigarette users, current and former cigarette users had higher odds of nocturia (AOR=1.12; 95% CI: 1.02–1.23; AOR=1.12; 95% CI: 1.01–1.24; all p<0.05) and UUI (AOR=1.23; 95% CI: 1.09–1.39; AOR=1.13; 95% CI: 1.03–1.24; all p<0.01). Compared to never e-cigarette users, current e-cigarette users had higher odds of nocturia (AOR=1.43; 95% CI: 1.01–2.02; p<0.05) and UUI (AOR=1.56; 95% CI: 1.13–2.16; p<0.01) and former e-cigarette users had higher odds of UUI (AOR=1.29; 95% CI: 1.02–1.62; p<0.05). Dual users of cigarettes and e-cigarettes had higher odds of nocturia (AOR=1.61; 95% CI: 1.03–2.51; p<0.05) and UUI (AOR=1.79; 95% CI: 1.19–2.68; p<0.01) compared to never users. In participants with prostate cancer, current cigarette use was associated with higher odds of UUI (AOR=2.40; 95% CI: 1.04–5.57; p<0.05.
Conclusions:
This study found that cigarette use, e-cigarette use, and dual use were associated with higher odds of nocturia and UUI. Cohort studies are needed to determine the causality of this cross-sectional assessment.
ACKNOWLEDGEMENTS
We would like to express our thanks and appreciation to the individuals
who participated in NHANES and to the staff who made this research
possible.
CONFLICTS OF INTEREST
The authors have completed and submitted the ICMJE Form for
Disclosure of Potential Conflicts of Interest. The authors declare that
they have no competing interests, financial or otherwise, related to the
current work. All authors report that since the initial planning of the
work they received support from the Sanming Project of Medicine in
Shenzhen (Grant number: SZSM202011011).
FUNDING
This work was supported by the Sanming Project of Medicine in
Shenzhen (Grant number: SZSM202011011). The funders had no role in
the study design, collection, analysis, interpretation or writing of the
manuscript.
ETHICAL APPROVAL AND INFORMED CONSENT
Ethical approval and informed consent were not required for this study
as it used existing publicly available data.
DATA AVAILABILITY
The data supporting this research are publicly available at https://wwwn.cdc.gov/nchs/nhanes/Default.aspx
AUTHORS' CONTRIBUTIONS
XY, YX and JP: integrity of the data, accuracy of the data analysis,
concept and design. XY and YX: drafting of the manuscript. All authors:
data acquisition, analysis, and interpretation, revision of the manuscript.
HC, XY and YX: statistical analysis. JP: funding, administration, technical
or material support, supervision. All authors read and approved the final
version of the manuscript.
PROVENANCE AND PEER REVIEW
Not commissioned; externally peer-reviewed.
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