Smoking, haptoglobin and fertility in humans
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The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Division of Occupational Health Medicine, Department of Biopathology and Imaging Diagnostics, University of Rome, Tor Vergata, School of Medicine, Rome, Italy
Department of Medical Genetics, City of Hope National Medical Center, Duarte, California
Institute of Obstetrics and Gynecology, University of Rome La Sapienza, School of Medicine, Rome, Italy
Division of Medical Statistics, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy
F Gloria-Bottini   

Dipartimento di Biopatologia e Diagnostica per Immagini, Facolta di Medicina Via della Ricerca Scientifica, 1 00133, Roma, Italy
Submission date: 2002-01-17
Acceptance date: 2002-03-15
Publication date: 2002-03-15
Tobacco Induced Diseases 2002;1(March):3
A prospective study on two samples of consecutive puerperae (total n° 667) from two populations has been carried out in order to investigate the possible effect of smoking habit on relationship between fertility and haptoglobin phenotype. In both populations the negative association previously reported between age of pueperae and Haptoglobin *1/*1 phenotype is present only in women with smoking habit pointing to an interaction between Hp and smoke on human fertility. This suggests that the effects of smoke on fertility are dependent on the Hp phenotype.
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