Sensory properties of menthol and smoking topography

Although there is a great deal known about menthol as a flavoring agent in foods and confections, less is known about the particular sensory properties of menthol cigarette smoke. Similarly, although smoking topography (the unique way an individual smokes a cigarette) has been well studied using non-menthol cigarettes, there is relatively less known about how menthol affects smoking behavior. The objective of this review is to assess the sensory properties of menthol tobacco smoke, and smoking topography associated with menthol cigarettes. The cooling, analgesic, taste, and respiratory effects of menthol are well established, and studies have indicated that menthol’s sensory attributes can have an influence on the positive, or rewarding, properties associated smoking, including ratings of satisfaction, taste, perceived smoothness, and perceived irritation. Despite these sensory properties, the data regarding menthol’s effect on smoking topography are inconsistent. Many of the topography studies have limitations due to various methodological issues.

REFERENCES (47)

Harris B: Menthol: a review of its thermoreceptor interactions and their therapeutic applications. International Journal of Aromatherapy. 2006, 16 (3-4): 117-131. 10.1016/j.ijat.2006.09.010.

Google Scholar

Ahijevych K, Garrett BE: Menthol pharmacology and its potential impact on cigarette smoking behavior. Nicotine and Tobacco Research. 2004, 6 (suppl 1): S17-S28. 10.1080/14622200310001649469.

Google Scholar

Dessirier JM, O’Mahony M, et al: Oral irritant properties of menthol: sensitizing and desensitizing effects of repeated application and cross-desensitization to nicotine. Physiology and Behavior. 2001, 73 (1-2): 25-36. 10.1016/S0031-9384(01)00431-0.

Google Scholar

Eccles R, Jones AS: The effect of menthol on nasal resistance to air flow. The Journal of Laryngology and Otology. 1983, 97 (8): 705-709.

Google Scholar

Kuhn FJP, Kuhn C, et al: Inhibition of TRPM8 by icilin distinct from desensitiÂ¬zation induced by menthol and menthol derivatives. Journal of Biological Chemistry. 2009, 284 (7): 4102-4111. 10.1074/jbc.M806651200.

Google Scholar

McKemy DD: How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. Mol Pain. 2005, 1: 16-10.1186/1744-8069-1-16.

Google Scholar

Katsura H, Tsuzuki K, Noguchi K, Masafumi Sakagami: Differential Expression of Capsaicin-, Menthol-, and Mustard Oil-Sensitive Receptors in Naive Rat Geniculate Ganglion Neurons. Chem. Senses. 2006, 31 (7): 681-688. 10.1093/chemse/bjl009.

Google Scholar

Eccles R: Menthol and related cooling compounds. Journal of Pharmarcy and Pharmacology. 1994, 46 (8): 618-630. 10.1111/j.2042-7158.1994.tb03871.x.

Google Scholar

Campero M, Baumann TK, et al: Human cutaneous c fibres activated by cooling, heating, and menthol. Journal of Physiology. 2009, 587 (23): 5633-5652. 10.1113/jphysiol.2009.176040.

Google Scholar

10.

Ferris Wayne, Connolly GN: Application, function, and effects of menthol in cigarettes: a survey of tobacco industry documents. Nicotine and Tobacco Research. 2004, 6 (suppl 1): S43-S54.

Google Scholar

11.

Galeotti N, Di Cesare Mannelli, et al: Menthol: a natural analgesic compound. Neuroscience Letters. 2002, 322 (3): 145-148. 10.1016/S0304-3940(01)02527-7.

Google Scholar

12.

Sherkheli MA, Gisselmann G, et al: Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pakistan Journal of Pharmaceutical Sciences. 2008, 21 (4): 370-378.

Google Scholar

13.

Sant’Ambrogio FB, Anderson JW, et al: Effect of l-menthol on laryngeal receptors. Journal of Applied Physiology. 1991, 70 (2): 788-793.

Google Scholar

14.

Sekizawa SI, Tsubone H, et al: Nasal receptors responding to cold and l-menthol airflow in the guinea pig. Respiration Physiology. 1996, 103 (3): 211-219. 10.1016/0034-5687(95)00091-7.

Google Scholar

15.

Eccles R, Jawad MS, et al: The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. Journal of Pharmacy and Pharmacology. 1990, 42 (9): 652-654. 10.1111/j.2042-7158.1990.tb06625.x.

Google Scholar

16.

Eccles R, Jawad MSM, et al: The effects of L-Menthol on nasal resistance to air-flow and nasal sensation of air-flow in human volunteers suffering from acute upper respiratory-tract infection. Journal of Physiology-London. 1989, 417: P131.

Google Scholar

17.

Houghton TM, Beardsmore CS: The effect of menthol on nasal airflow, perception of nasal patency, and cough receptor sensitivity in children aged 10 and 11 years. Thorax. 1998, 53 (suppl 4): A9.

Google Scholar

18.

Nishino T, Tagaito Y, et al: Nasal inhalation of l-menthol reduces respiratory discomfort associated with loaded breathing. American Journal of Respiratory and Critical Care Medicine. 1997, 156 (1): 309-313.

Google Scholar

19.

Orani GP, Anderson JW, et al: Upper airway cooling and l-menthol reduce ventilation in the guinea pig. Journal of Applied Physiology. 1991, 70 (5): 2080-2086.

Google Scholar

20.

Sant’Ambrogio FB, Anderson JW, et al: Menthol in the upper airway depresses ventilation in newborn dogs. Respiration Physiology. 1992, 89 (3): 299-307. 10.1016/0034-5687(92)90088-E.

Google Scholar

21.

Sloan A, De Cort SC, et al: Prolongation of breath-hold time following treatment with an L-menthol lozenge in healthy man. Journal of Physiology. 1993, 473: 53P.

Google Scholar

22.

Wright CE, Laude EA, et al: Capsaicin and neurokinin A-induced bronchoconstriction in the anaesthetised guinea-pig: evidence for a direct action of menthol on isolated bronchial smooth muscle. British Journal of Pharmacology. 1997, 121 (8): 1645-1650. 10.1038/sj.bjp.0701319.

Google Scholar

23.

Ito S, Kume H, et al: Inhibition by the cold receptor agonists menthol and icilin of airway smooth muscle contraction. Pulmonary Pharmacology and Therapeutics. 2008, 21 (5): 812-817. 10.1016/j.pupt.2008.07.001.

Google Scholar

24.

Laude EA, Morice AH, et al: The antitussive effects of menthol, camphor and cineole in conscious guinea-pigs. Pulmonary Pharmacology. 1994, 7 (3): 179-184. 10.1006/pulp.1994.1021.

Google Scholar

25.

Green BG, Schullery MT: Stimulation of bitterness by capsaicin and menthol: differences between lingual areas innervated by the glossopharyngeal and chorda tympani nerves. Chemical Senses. 2003, 28 (1): 45-55. 10.1093/chemse/28.1.45.

Google Scholar

26.

Duner-Engstrom M, Larsson O, et al: Effect of nicotine chewing gum on salivary secretion. Swedish Dental Journal. 1986, 10 (3): 93-96.

Google Scholar

27.

Clark PI, Gautam S, et al: Effect of menthol cigarettes on biochemical markers of smoke exposure among black and white smokers. Chest. 1996, 110 (5): 1194-1198. 10.1378/chest.110.5.1194.

Google Scholar

28.

Hymowitz N, Mouton C, Edkholdt H: Menthol cigarette smoking in African Americans and Whites. Tobacco Control. 1995, 4: 194-195. 10.1136/tc.4.2.194b.

Google Scholar

29.

Levin ED, Behm F, et al: The use of flavor in cigarette substitutes. Drug and Alcohol Dependence. 1990, 26 (2): 155-160. 10.1016/0376-8716(90)90122-U.

Google Scholar

30.

Kreslake JM, Wayne GF, et al: The menthol smoker: tobacco industry research on consumer sensory perception of menthol cigarettes and its role in smoking behavior. Nicotine and Tobacco Research. 2008, 10 (4): 705-715. 10.1080/14622200801979134.

Google Scholar

31.

Ahijevych K, Gillespie J, et al: Menthol and nonmenthol cigarettes and smoke exposure in black and white women. Pharmacology Biochemistry, and Behavior. 1996, 53 (2): 355-360. 10.1016/0091-3057(95)02034-9.

Google Scholar

32.

Ahijevych K, Parsley LA: Smoke constituent exposure and stage of change in black and white women cigarette smokers. Addictive Behaviors. 1999, 24 (1): 115-120. 10.1016/S0306-4603(98)00031-8.

Google Scholar

33.

Jarvik ME, Tashkin DP, et al: Mentholated cigarettes decrease puff volume of smoke and increase carbon monoxide absorption. Physiology and Behavior. 1994, 56 (3): 563-570. 10.1016/0031-9384(94)90302-6.

Google Scholar

34.

McCarthy WJ, Caskey NH, et al: Menthol vs. nonmenthol cigarettes: effects on smoking behavior. American Journal of Public Health. 1995, 85 (1): 67-72. 10.2105/AJPH.85.1.67.

Google Scholar

35.

Miller GE, Jarvik ME, et al: Cigarette mentholation increases smokers’ exhaled carbon monoxide levels. Experimental and Clinical Psychopharmacology. 1994, 2 (2): 154-160. 10.1037/1064-1297.2.2.154.

Google Scholar

36.

Strasser AA, Milaiyandi V, et al: An association of CYP2A6 genotype and smoking topography. Nicotine and Tobacco Research. 2007, 9 (4): 511-518. 10.1080/14622200701239605.

Google Scholar

37.

Nil R, Battig K: Separate effects of cigarette smoke yield and smoke taste on smoking behavior. Psychopharmacology (Berl). 1989, 99 (1): 54-59. 10.1007/BF00634452.

Google Scholar

38.

Caskey NH, Jarvik ME, et al: Rapid smoking of menthol and nonmenthol cigarettes by black and white smokers. Pharmacology Biochemistry, and Behavior. 1993, 46 (2): 259-263. 10.1016/0091-3057(93)90350-3.

Google Scholar

39.

Moolchan ET, Hudson DL, et al: Heart rate and blood pressure responses to tobacco smoking among African-American adolescents. Journal of the National Medical Association. 2004, 96 (6): 767-771.

Google Scholar

40.

Sidney S, Tekawa I, et al: Mentholated cigarette use among multiphasic examinees, 1979–86. American Journal of Public Health. 1989, 79 (10): 1415-1416. 10.2105/AJPH.79.10.1415.

Google Scholar

41.

Pickworth WB, Moolchan ET, et al: Sensory and physiologic effects of menthol and non-menthol cigarettes with differing nicotine delivery. Pharmacology Biochemistry, and Behavior. 2002, 71 (1-2): 55-61. 10.1016/S0091-3057(01)00623-2.

Google Scholar

42.

Garten S, Falkner RV: Role of mentholated cigarettes in increased nicotine dependence and greater risk of tobacco-attributable disease. Preventive Medicine. 2004, 38 (6): 793-798. 10.1016/j.ypmed.2004.01.019.

Google Scholar

43.

Celebucki CC, Wayne GF, et al: Characterization of measured menthol in 48 U.S. cigarette sub-brands. Nicotine and Tobacco Research. 2005, 7 (4): 523-531. 10.1080/14622200500186270.

Google Scholar

44.

Pritchard WS, Houlihan ME, et al: Little evidence that “denicotinized” menthol cigarettes have pharmacological effects: an EEG/heart-rate/subjective-response study. Psychopharmacology (Berl). 1999, 143 (3): 273-279. 10.1007/s002130050947.

Google Scholar

45.

Rose JE, Behm FM: Extinguishing the rewarding value of smoke cues: pharmacological and behavioral treatments. Nicotine and Tobacco Research. 2004, 6 (3): 523-532. 10.1080/14622200410001696501.

Google Scholar

46.

McKemy DD: TRPM8: The Cold and Menthol Receptor. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Edited by: Liedtke WB, Heller S. 2007, Boca Raton (FL): CRC Press, Chapter 13.Frontiers in Neuroscience.

Google Scholar

47.

Ahijevych K, Garrett BE: The role of menthol in cigarettes as a reinforcer of smoking behavior. Nicotine and Tobacco Research. 2010, S110-6. 10.1093/ntr/ntq203. Suppl 2.

Google Scholar

CITATIONS (7):

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