Scratching the surface – tobacco-induced bacterial biofilms
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Departments of Microbiology and Immunology, University of Louisville, Louisville, USA
Oral Immunology and Infectious Diseases, University of Louisville, Louisville, USA
Pediatrics, Washington University School of Medicine, Saint Louis, USA
David A. Scott   

Oral Immunology and Infectious Diseases, University of Louisville, 501 South Preston Street, Louisville, KY 40292, USA
Publish date: 2015-02-10
Tobacco Induced Diseases 2015;13(February):1
Individual environmental factors, such as iron, temperature and oxygen, are known to have a profound effect on bacterial phenotype. Therefore, it is surprising so little known is about the influence of chemically complex cigarette smoke on bacterial physiology. Recent evidence has demonstrated that tobacco smoke and components alter the bacterial surface and promote biofilm formation in several important human pathogens, including Staphylococcus aureus, Streptococcus mutans, Klebsiella pneumonia, Porphyromonas gingivalis and Pseudomonas aeruginosa. The mechanisms underlying this phenomenon and the relevance to increased susceptibility to infectious disease in smokers and to treatment are reviewed.
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