RESEARCH PAPER
Relationship between smoking and a new index of arterial stiffness, the cardio-ankle vascular index, in male workers: a cross-sectional study
| 1 | Department of Work Systems and Health, Institute of Industrial Ecological
Science, University of Occupational and Environmental Health, Kitakyusyu, Fukuoka, Japan |
| 2 | Hitachi Health Care Center, Hitachi
Ltd., Ibaraki, Japan |
CORRESPONDING AUTHOR
Koichi Hata
Department of Work Systems and Health, Institute of Industrial Ecological Science, University of Occupational and Environmental Health, 1-1 Iseigaoka, Kitakyusyu, 811-4341 Fukuoka, Japan
Department of Work Systems and Health, Institute of Industrial Ecological Science, University of Occupational and Environmental Health, 1-1 Iseigaoka, Kitakyusyu, 811-4341 Fukuoka, Japan
Publish date: 2012-07-28
Tobacco Induced Diseases 2012;10(July):11
KEYWORDS
ABSTRACT
Background:
Cigarette smoking is one of the major factors that increases arterial stiffness. The purpose of this study was to examine further the relationship between smoking status and arterial stiffness using a new index, the cardio-ankle vascular index (CAVI), in male Japanese workers.
Methods:
This cross-sectional study included 4,729 male Japanese workers undergoing annual health checkups. CAVI was measured at the time of the annual health checkup between April 2007 and March 2008. The subjects were divided into three groups, smokers (n = 1,913), former smokers (n = 1,481) and non-smokers (n = 1,348) according to their responses to a questionnaire. We compared the CAVI in the three groups after adjusting for age. Multiple regression analysis was used to examine the association between CAVI and the number of cigarettes smoked per day in order to examine whether there was a dose–response relationship between smoking and CAVI.
Results:
The mean CAVI for each group was 7.81 ± 0.02 for smokers, 7.70 ± 0.02 for former smokers and 7.64 ± 0.02 for non-smokers. A significant difference was observed between each group. According to the results of multiple regression analysis, the standardized β of the number of cigarettes smoked per day was 0.09 (p < 0.01). This confirmed a positive association with CAVI.
Conclusions:
Our study demonstrated that there is a significant association between the number of cigarettes smoked per day and arterial stiffness, as measured by CAVI.
Cigarette smoking is one of the major factors that increases arterial stiffness. The purpose of this study was to examine further the relationship between smoking status and arterial stiffness using a new index, the cardio-ankle vascular index (CAVI), in male Japanese workers.
Methods:
This cross-sectional study included 4,729 male Japanese workers undergoing annual health checkups. CAVI was measured at the time of the annual health checkup between April 2007 and March 2008. The subjects were divided into three groups, smokers (n = 1,913), former smokers (n = 1,481) and non-smokers (n = 1,348) according to their responses to a questionnaire. We compared the CAVI in the three groups after adjusting for age. Multiple regression analysis was used to examine the association between CAVI and the number of cigarettes smoked per day in order to examine whether there was a dose–response relationship between smoking and CAVI.
Results:
The mean CAVI for each group was 7.81 ± 0.02 for smokers, 7.70 ± 0.02 for former smokers and 7.64 ± 0.02 for non-smokers. A significant difference was observed between each group. According to the results of multiple regression analysis, the standardized β of the number of cigarettes smoked per day was 0.09 (p < 0.01). This confirmed a positive association with CAVI.
Conclusions:
Our study demonstrated that there is a significant association between the number of cigarettes smoked per day and arterial stiffness, as measured by CAVI.
REFERENCES (18)
| 1. | Murray CJ, Lopez AD: Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet. 1997, 349: 1498-1504. 10.1016/S0140-6736(96)07492-2. |
| 2. | O'Rourke MF, Hashimoto J: Mechanical factors in arterial aging: a clinical perspective. JACC. 2007, 50: 1-13. |
| 3. | Kubo T, Miyata M, Minagoe S, Setoyama S, Maruyama I, Tei C: A simple oscillometric technique for determining new indices of arterial distensibility. Hypertens Res. 2002, 25: 351-358. 10.1291/hypres.25.351. |
| 4. | Shirai K, Utino J, Otsuka K, Takata M: A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb. 2006, 13: 101-107. 10.5551/jat.13.101. |
| 5. | Yambe T, Meng X, Hou X, Wang Q, Sekine K, Shiraishi Y, Watanabe M, Yamaguchi T, Shibata M, Kuwayama T, Murayam M, Konno S, Nitta S: Cardio-ankle vascular index (CAVI) for the monitoring of the atherosclerosis after heart transplantation. Biomed Pharmacother. 2005, 59 (Suppl 1): S177-S179. |
| 6. | Kadota K, Takamura N, Aoyagi K, Yamasaki H, Usa T, Nakazato M, Maeda T, Wada M, Nakashima K, Abe K, Takeshima F, Ozono Y: Availability of cardio-ankle vascular index (CAVI) as a screening tool for atherosclerosis. Circ J. 2008, 72: 304-308. 10.1253/circj.72.304. |
| 7. | Izuhara M, Shioji K, Kadota S, Baba O, Takeuchi Y, Uegaito T, Mutsuo S, Matsuda M: Relationship of Cardio-Ankle Vascular Index (CAVI) to Carotid and Coronary Arteriosclerosis. Circ J. 2008, 72: 1762-1767. 10.1253/circj.CJ-08-0152. |
| 8. | Yufu K, Takahashi N, Hara M, Saikawa T, Yoshimatsu H: Measurement of the brachial-ankle pulse wave velocity and flow-mediated dilatation in young, healthy smokers. Hypertens Res. 2007, 30: 607-612. 10.1291/hypres.30.607. |
| 9. | Tomiyama H, Yamazaki M, Sagawa Y, Teraoka K, Shirota T, Miyawaki Y, Yamashina A: Synergistic effect of smoking and blood pressure on augmentation index in men, but not in women. Hypertens Res. 2009, 32: 122-126. 10.1038/hr.2008.20. |
| 10. | Wiesmann F, Petersen SE, Leeson PM, Francis JM, Robson MD, Wang Q, Choudhury R, Channon KM, Neubauer S: Global impairment of brachial, carotid, and aortic vascular function in young smokers: direct quantification by high-resolution magnetic resonance imaging. J Am Coll Cardiol. 2004, 44: 2056-2064. 10.1016/j.jacc.2004.08.033. |
| 11. | Virtanen MP, Koobi T, Turjanmaa VM, Majahalme S, Tuomisto MT, Nieminen T, Kahonen M: Predicting arterial stiffness with ambulatory blood pressure: an 11-year follow-up. Clin Physiol Funct Imaging. 2008, 28: 378-383. 10.1111/j.1475-097X.2008.00817.x. |
| 12. | Seltzer CC: Framingham study data and "established wisdom" about cigarette smoking and coronary heart disease. JCE. 1989, 42: 743-750. |
| 13. | Kiyohara Y, Ueda K, Fujishima M: Smoking and Cardiovascular-Disease in the General-Population in Japan. J Hypertens. 1990, 8: S9-S15. 10.1097/00004872-199006002-00003. |
| 14. | Shimozato M, Nakayama T, Yokoyama T, Yoshi-ike N, Yamaguchi M, Date C: A 15.5-year cohort study on risk factors for possible myocardial infarction and sudden death within 24 hours in a rural Japanese community. J Epidemiol. 1996, 6: 15-22. 10.2188/jea.6.15. |
| 15. | Shimamoto T, Komachi Y, Inada H, Doi M, Iso H, Sato S, Kitamura A, Iida M, Konishi M, Nakanishi N: Trends for coronary heart disease and stroke and their risk factors in Japan. Circulation. 1989, 79: 503-515. 10.1161/01.CIR.79.3.503. |
| 16. | Konishi M, Iso H, Iida M, Naito Y, Sato S, Komachi Y, Shimamoto T, Doi M, Ito M: Trends for coronary heart disease and its risk factors in Japan: epidemiologic and pathologic studies. Jpn Circ J. 1990, 54: 428-435. 10.1253/jcj.54.428. |
| 17. | Yanbaeva DG, Dentener MA, Creutzberg EC, Wesseling G, Wouters EF: Systemic effects of smoking. Chest. 2007, 131: 1557-1566. 10.1378/chest.06-2179. |
| 18. | Iso H, Date C, Yamamoto A, Toyoshima H, Watanabe Y, Kikuchi S, Koizumi A, Wada Y, Kondo T, Inaba Y, Tamakoshi A: Smoking cessation and mortality from cardiovascular disease among Japanese men and women: the JACC Study. Am J Epidemiol. 2005, 161: 170-179. 10.1093/aje/kwi027. |
CITATIONS (6):
| 1. |
Smoking: A risk factor for vascular disease Phyllis Gordon, Patty Flanagan Journal of Vascular Nursing |
| 2. |
Associations between smoking and alcohol use and arterial elasticity in patients with newly diagnosed essential hypertension: A cross-sectional study Noor-Ahmed Jatoi, Waleed-Ibrahim Al-Baker, Afnan Al-Muhanna, Fahad Al-Muhanna, Stella-Maria Kyvelou, Faisal Sharif Artery Research |
| 3. |
Relationship between Overtime Work Hours and Cardio-ankle Vascular Index (CAVI): A Cross-sectional Study in Japan Koichi Hata, Toru Nakagawa, Masayuki Hasegawa, Hiroko Kitamura, Takeshi Hayashi, Akira Ogami Journal of Occupational Health |
| 4. |
Aortic dissection in children and adolescents with Turner syndrome: risk factors and management recommendations: Table 1 E J Turtle, A A Sule, D J Webb, L E Bath Archives of Disease in Childhood |
| 5. |
Smoking and Female Sex: Independent Predictors of Human Vascular Smooth Muscle Cells Stiffening Carla Luana Dinardo, Hadassa Campos Santos, André Ramos Vaquero, André Ricardo Martelini, Luis Alberto Oliveira Dallan, Adriano Mesquita Alencar, José Eduardo Krieger, Alexandre Costa Pereira, Rudolf Kirchmair PLOS ONE |
| 6. |
Arterial stiffness and cognitive impairment Xiaoxuan Li, Peiyuan Lyu, Yanyan Ren, Jin An, Yanhong Dong Journal of the Neurological Sciences |
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