RESEARCH PAPER
Lipid and lipoprotein profiles among middle aged male smokers: a study from southern India
 
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1
Madras Medical College, Chennai, India
2
Chennai Medical College Hospital & Research Center, Trichy, India
CORRESPONDING AUTHOR
Ramachandran Meenakshisundaram   

Madras Medical College, Chennai, India
Publish date: 2010-10-05
 
Tobacco Induced Diseases 2010;8(October):11
KEYWORDS
ABSTRACT
Objectives:
The objectives were to investigate into the relationship between lipid profile including ApolipoproteinA1 (Apo-A1) and Apolipoprotein-B (Apo-B) and smokers and to relate them with smoking pack years.

Materials and Methods:
A total of 274 active male smokers without any other illnesses and age matched male healthy control subjects (78) with similar socio-cultural background were assessed for clinical details, dietary habits, physical activities, smoking and alcohol consumption. Standard methods were adopted to check the lipid levels. The data were analyzed statistically.

Results:
Their ages ranged from 40 to 59 years, systolic BP from 110 to 130 mmHg, and diastolic BP from 76 to 88 mmHg. All of them had similar pattern of diet (vegetarianism with occasional meat). None was on any medication influences lipid level. Their physical activity was moderate. Number of pack years varied from 10 to 14 (mild), 15 to 19 (moderate) and 20 and above (heavy) among 69, 90 and 115 cases, whose mean ages were 43, 44 and 49 respectively. The mean (+SD) values in mg/dl of total cholesterol (TC), Triglyceride (TGL), Apo-B, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol and Apo-A1 in mg/dl among mild/ moderate/ heavy smokers and control subjects were 198 (30.6)/ 224 (27.2)/ 240 (24.3) and 160 (20.4); 164(42.6)/ 199 (39.5)/ 223(41.7) and 124 (31.6); 119 (24.9)/ 121 (27)/ 127 (28.3) and 116 (21.4); 94 (19.7)/ 104 (21.8)/ 120 (20.5) and 82 (17.6); 42 (5.9)/ 39 (3.1)/ 35(4.4) and 48 (5.3); and 120 (17)/ 119 (21)/ 115 (25) and 126 (19), respectively. In smokers, there was a rise in TC, TGL, LDL, Apo-B and fall in HDL and Apo-A; these changes were significant (P < 0.05).

Conclusions:
Number of pack years was directly proportional to abnormal lipid profile. It is also concluded that changes in Apo-A1 and Apo-B were more significant when compared to HDL and LDL cholesterol among smokers. In the view of double risk for smokers (smoking and altered lipid profile) efforts may be made to introduce smoking cessation program.

 
REFERENCES (39)
1.
Loeper J, Goy J, Rozensztajn L, Bedu O, Moisson P: Lipid peroxidation and protective enzymes during myocardial infarction. Clin Chim Acta. 1991, 196: 119-125. 10.1016/0009-8981(91)90064-J.
 
2.
Stary H, Chandler A, Glagov S, Guyton J, Insull WJ, Rosenfeld M, Schaffer S, Schwartz C, Wagner W, Wissler R: A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb. 1994, 14: 840-856.
 
3.
Prevalence of tobacco use. 2004, New Delhi: Ministry of Health and Family Welfare, Govt. of India.
 
4.
Rani M, Bonu S, Jha P, Nguyen S, Jamjoum L: Tobacco use in India: prevalence and predictors of smoking and chewing in a national cross sectional household survey. Tob Control. 2003, 12: e4-10.1136/tc.12.4.e4.
 
5.
Brischetto C, Connor W, Connor S, Matarazzo J: Plasma lipid and lipoprotein profiles of cigarette smokers from randomly selected families: enhancement of hyperlipidemia and depression of high-density lipoprotein. Am J Cardiol. 1983, 52: 675-680. 10.1016/0002-9149(83)90396-X.
 
6.
Kharb S, Singh G: Effect of smoking on lipid profile, lipid peroxidation and antioxidant status in normal subjects and in patients during and after acute myocardial infarction. Clin Chim Acta. 2000, 302: 213-219. 10.1016/S0009-8981(00)00343-0.
 
7.
Craig W, Palomaki G, Haddow J: Cigarette smoking and serum lipid and lipoprotein concentrations: an analysis of published data. BMJ. 1989, 298: 784-788. 10.1136/bmj.298.6676.784.
 
8.
Whig J, Singh C, Soni G, Bansal A: Serum lipids & lipoprotein profiles of cigarette smokers & passive smokers. Indian J Med Res. 1992, 96: 282-287.
 
9.
NS Neki: Lipid Profile in Chronic Smokers - A Clinical Study. JIACM. 2002, 3: 51-54.
 
10.
Venkatesan A, Hemalatha A, Bobby Z, Selvaraj N, Sathiyapriya V: Effect of smoking on lipid profile and lipid peroxidation in normal subjects. Indian J Physiol Pharmacol. 50: 273-278.
 
11.
Assmann G, Schriewer H, Schmitz G, Hägele E: Quantification of high-density-lipoprotein cholesterol by precipitation with phosphotungstic acid/MgCl2. Clin Chem. 1983, 29: 2026-2030.
 
12.
Statpages.org. 2010, [http://statpages.org/#Comparis...].
 
13.
Akbari ZA BM, Shakoor M: Lipid profile in smoking. JAMC. 2000, 12: 19-21.
 
14.
Mammas I, Bertsias G, Linardakis M, Tzanakis N, Labadarios D, Kafatos A: Cigarette smoking, alcohol consumption, and serum lipid profile among medical students in Greece. Eur J Public Health. 2003, 13: 278-282. 10.1093/eurpub/13.3.278.
 
15.
Johnkennedy N: Effect of smoking on lipid profile among adult smokers in Owerri, Nigeria. Journal of Medical Laboratory Science. 2010, 1 (2).
 
16.
Raftopoulos CBM, Steinbeck KS: Coronary heart disease risk factors in male adolescents with particular reference to smoking and blood lipids. J Adolesc Health. 1999, 25 (1): 68-74. 10.1016/S1054-139X(98)00130-X.
 
17.
Elovson J, Chatterton J, Bell G, Schumaker V, Reuben M, Puppione D, Reeve JJ, Young N: Plasma very low density lipoproteins contain a single molecule of apolipoprotein B. J Lipid Res. 1988, 29: 1461-1473.
 
18.
Khan DA IA, khan FA: The effects of cigarette smoking on apolipoprotein A1 and apolipoprotein B. Pak J Pathol. 1997, 8: 38-45.
 
19.
Neufeld E, Mietus-Snyder M, Beiser A, Baker A, Newburger J: Passive cigarette smoking and reduced HDL cholesterol levels in children with high-risk lipid profiles. Circulation. 1997, 96: 1403-1407.
 
20.
Goh E, Heimberg M: Stimulation of hepatic cholesterol biosynthesis by oleic acid. Biochem Biophys Res Commun. 1973, 55: 382-388. 10.1016/0006-291X(73)91098-X.
 
21.
Muscat J, Harris R, Haley N, Wynder E: Cigarette smoking and plasma cholesterol. Am Heart J. 1991, 121: 141-147. 10.1016/0002-8703(91)90967-M.
 
22.
HL B: Pharmacologic aspects of cigarette smoking and nicotine addiction. New Engl J Med. 1988, 319: 1318-1330. 10.1056/NEJM198811173192005.
 
23.
Reaven G: Role of insulin resistance in human disease. 1988, 37: 595-607.
 
24.
Freeman D, Caslake M, Griffin B, Hinnie J, Tan C, Watson T, Packard C, Shepherd J: The effect of smoking on post-heparin lipoprotein and hepatic lipase, cholesteryl ester transfer protein and lecithin:cholesterol acyl transferase activities in human plasma. Eur J Clin Invest. 1998, 28: 584-591. 10.1046/j.1365-2362.1998.00328.x.
 
25.
Freeman D, Griffin B, Murray E, Lindsay G, Gaffney D, Packard C, Shepherd J: Smoking and plasma lipoproteins in man: effects on low density lipoprotein cholesterol levels and high density lipoprotein subfraction distribution. Eur J Clin Invest. 1993, 23: 630-640. 10.1111/j.1365-2362.1993.tb00724.x.
 
26.
Moriguchi E, Fusegawa Y, Tamachi H, Goto Y: Effects of smoking on HDL subfractions in myocardial infarction patients: effects on lecithin-cholesterol acyltransferase and hepatic lipase. Clin Chim Acta. 1991, 195: 139-143. 10.1016/0009-8981(91)90134-X.
 
27.
Eliasson B, Mero N, Taskinen M, Smith U: The insulin resistance syndrome and postprandial lipid intolerance in smokers. Atherosclerosis. 1997, 129: 79-88. 10.1016/S0021-9150(96)06028-5.
 
28.
Packard C, Shepherd J: Lipoprotein metabolism in lipase deficient states: studies in primary and secondary hyperlipidaemia. Biochem Soc Trans. 1993, 21: 503-506.
 
29.
McCall M, van den Berg J, Kuypers F, Tribble D, Krauss R, Knoff L, Forte T: Modification of LCAT activity and HDL structure. New links between cigarette smoke and coronary heart disease risk. Arterioscler Thromb. 1994, 14: 248-253.
 
30.
Ashakumary L, Vijayammal P: Effect of nicotine on lipoprotein metabolism in rats. Lipids. 1997, 32: 311-315. 10.1007/s11745-997-0038-8.
 
31.
Li H, Liu D, Liang C: Paraoxonase gene polymorphisms, oxidative stress, and diseases. J Mol Med. 2003, 81: 766-779. 10.1007/s00109-003-0481-4.
 
32.
Oda M, Bielicki J, Ho T, Berger T, Rubin E, Forte T: Paraoxonase 1 overexpression in mice and its effect on high-density lipoproteins. Biochem Biophys Res Commun. 2002, 290: 921-927. 10.1006/bbrc.2001.6295.
 
33.
Shih D, Gu L, Xia Y, Navab M, Li W, Hama S, Castellani L, Furlong C, Costa L, Fogelman A, Lusis A: Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature. 1998, 394: 284-287. 10.1038/28406.
 
34.
Sanchez Bayle M, Gonzalez Requejo A, Ruiz-Jarabo C, Vila S, Arnaiz P, Asensio J, Baeza J: Smoking and apolipoproteins in adolescents. The Niño Jesus Group. J Adolesc Health. 1992, 13: 524-527. 10.1016/1054-139X(92)90018-7.
 
35.
Fisher S, Zareba W, Moss A, Marder V, Sparks C, Hochman J, Liang C, Krone R: Effect of smoking on lipid and thrombogenic factors two months after acute myocardial infarction. Am J Cardiol. 2000, 86: 813-818. 10.1016/S0002-9149(00)01098-5.
 
36.
Durrington P, Hunt L, Ishola M, Kane J, Stephens W: Serum apolipoproteins AI and B and lipoproteins in middle aged men with and without previous myocardial infarction. Br Heart J. 1986, 56: 206-212. 10.1136/hrt.56.3.206.
 
37.
Maciejko J, Holmes D, Kottke B, Zinsmeister A, Dinh D, Mao S: Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease. N Engl J Med. 1983, 309: 385-389. 10.1056/NEJM198308183090701.
 
38.
Freedman D, Srinivasan S, Shear C, Franklin F, Webber L, Berenson G: The relation of apolipoproteins A-I and B in children to parental myocardial infarction. N Engl J Med. 1986, 315: 721-726. 10.1056/NEJM198609183151202.
 
39.
Stubbe I, Eskilsson J, Nilsson-Ehle P: High-density lipoprotein concentrations increase after stopping smoking. Br Med J (Clin Res Ed). 1982, 284: 1511-1513. 10.1136/bmj.284.6328.1511.
 
 
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