SHORT REPORT
Impact of smoking history on the association between Eicosapentaenoic acid to arachidonic acid ratio and acute coronary syndrome: A multicenter cross-sectional study
 
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1
Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
2
Department of Cardiology, Nihon University Hospital, Tokyo, Japan
3
Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
4
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
5
Department of Internal Medicine, Tokyo Takanawa Hospital, Tokyo, Japan
6
Department of Biostatistics, School of Public Health, The University of Tokyo, Tokyo, Japan
7
Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
8
Jichi Medical University, Shimotsuke-shi, Tochigi-ken, Japan
CORRESPONDING AUTHOR
Hiroyuki Daida   

Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyoku, Tokyo 113-8421, Japan
Publish date: 2018-03-16
 
Tob. Induc. Dis. 2018;16(March):8
KEYWORDS
TOPICS
Smoking
 
ABSTRACT
Introduction:
The association among smoking history, eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio and acute coronary syndrome (ACS) is yet to be investigated. The present study aimed to clarify the association between the EPA/AA ratio and ACS prevalence in patients admitted to the cardiology department based on their smoking history.

Material and Methods:
We enrolled 1733 patients from five cardiology divisions located in Tokyo, Japan, and measured their levels of polyunsaturated fatty acids, including EPA and AA, from January 2004 to May 2011. We assessed the association between the EPA/AA ratio and ACS in the subgroups stratified according to smoking history (never, former, current smokers) using multivariate logistic models.

Results:
A high EPA/AA ratio was significantly associated with decreased odds of ACS among patients without a smoking history (adjusted odds ratio AOR=0.20, 95% CI: 0.04–0.86) but not in patients with a smoking history (former smoker, AOR=1.50, 95% CI: 0.44–5.03; current smoker, AOR=3.73, 95% CI: 0.34–40.6).

Conclusions:
The EPA/AA ratio and ACS occurrence were found to be significantly associated in patients without a smoking history; however, no such association existed in patients with a smoking history.

 
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