Impact of Nicotine Replacement Therapy on Post-Cessation Mood Profile by Pre-Cessation Depressive Symptoms
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Tobacco Dependence Treatment and Research, Harvard School of Dental Medicine, Boston, USA
Department of Public Health, University of Helsinki, Finland
This study was conducted within the Harvard School of Dental Medicine, Boston, USA
Smoking Cessation Research Program, Harvard School of Dental Medicine, Boston, USA
Publication date: 2006-08-15
Tobacco Induced Diseases 2006;3(August):17
We evaluated the effects of Nicotine Replacement Therapy (NRT) on the Profile of Mood States (POMS), testing whether pre-cessation depressive symptoms modify NRT's effects on POMS. Out of 608 smokers attempting to quit with NRT, this secondary analysis included 242 participants abstinent for at least two weeks. We measured pre-cessation depressive symptoms with the Center for Epidemiological Studies Depression Scale. At 1, 7, and 14 post-cessation days we examined 6 self-reported POMS, i.e. feeling 'anxious', 'sad', 'confused', 'angry', 'energetic' and 'fatigue'. The results of the ANCOVA models suggested no NRT effects on feeling anxious, energetic or fatigue. We found that pre-cessation depression modified NRT effects in some specific mood states, such as depression by NRT- interaction effects on feeling confused and feeling angry. On average, the depressed participants in the placebo groups had the highest symptom scores. However, those depressed in NRT conditions did not have significantly higher symptom scores compared to the non-depressed groups. In treating those negative moods NRT may be particularly important for persons with depressive symptoms before cessation.
Doll R, Peto R, Boreham J, Sutherland I: Mortality in relation to smoking: 50 years' observations on male British doctors. BMJ. 2004, 328 (7455): 1519-10.1136/bmj.38142.554479.AE.
Fiore MC, Bailey WC, Cohen SJ, Dorfman SF, Goldstein MG, Gritz ER: Treating tobacco use and dependence. Clinical practice guideline. 2000, Rockville, MD: U.S. Department of Health and Human Services.
American Psychiatric Association AP: Diagnostic and statistical manual of mental disorders. Washington, DC. 1994, 4.
Abrams DB, Niaura R, Brown RA, Emmons KM, Goldstein MG, Monti PM: The Tobacco Dependence Treatment Handbook: A Guide to Best Practices. 2003, New York NY: The Guilford Press.
Kahler CW, Brown RA, Ramsey SE, Niaura R, Abrams DB, Goldstein MG: Negative mood, depressive symptoms, and major depression after smoking cessation treatment in smokers with a history of major depressive disorder. Journal of Abnormal Psychology. 2002, 111 (4): 670-675. 10.1037/0021-843X.111.4.670.
McNair DM, Lorr M, Droppelman LF: EDITS Manual for the profile of mood states. 1981, San Diego (CA): Educational and Industrial Testing Service.
Ward MM, Swan GE, Jack LM: Self-reported abstinence effects in the first month after smoking cessation. Addictive Behaviors. 2001, 26 (3): 311-327. 10.1016/S0306-4603(00)00107-6.
Transdermal Nicotine Study Group: Transdermal nicotine for smoking cessation. Six-month results from two multicenter controlled clinical trials. Journal of the American Medical Association. 1991, 266 (22): 3133-3138. 10.1001/jama.266.22.3133.
Cook MR, Gerkovich MM, Graham C, Hoffman SJ, Peterson RC: Effects of the nicotine patch on performance during the first week of smoking cessation. Nicotine & Tobacco Research. 2003, 5 (2): 141-144. 10.1080/1462220031000074873.
Fagerstrom KO, Schneider NG, Lunell E: Effectiveness of nicotine patch and nicotine gum as individual versus combined treatments for tobacco withdrawal symptoms. Psychopharmacology. 1993, 111: 271-277. 10.1007/BF02244941.
Gentry MV, Hammersley JJ, Hale CR, Nuwer PK, Meliska CJ: Nicotine patches improve mood and response speed in a lexical decision task. Addictive Behaviors. 2000, 25 (4): 549-557. 10.1016/S0306-4603(00)00072-1.
Covey L: Comments on "History of depression and smoking cessation outcome: a meta-analysis". Nicotine & Tobacco Research. 2004, 6 (4): 743-745. 10.1080/14622200410001727902. author reply 747–749; discussion 751–742.
Hitsman B, Borrelli B, McChargue DE, Spring B, Niaura R: History of depression and smoking cessation outcome: a meta-analysis. Journal of Consulting and Clinical Psychology. 2003, 71 (4): 657-663. 10.1037/0022-006X.71.4.657.
Piasecki T, Kenford S, Smith S, Fiore M, Baker T: Listening to nicotine: negative affect and the smoking withdrawal conundrum. Psychological Science. 1997, 8: 184-189. 10.1111/j.1467-9280.1997.tb00409.x.
Sanders D, Preveler R, Mant D, Fowler G: Predictors of successful smoking cessation following advice from nurses in general practice. Addiction. 1993, 88: 1699-1705. 10.1111/j.1360-0443.1993.tb02045.x.
Anda RF, Williamson DF, Escobedo LG, Mast EE, Giovino GA, Remington PL: Depression and the dynamics of smoking. The Journal of the American Medical Association. 1990, 264 (12): 1541-1545. 10.1001/jama.264.12.1541.
Glassman AH: Cigarette smoking: Implications for psychiatric illness. American Journal of Psychiatry. 1993, 150 (4): 546-553.
Haustein KO, Haffner S, Woodcock BG: A review of the pharmacological and psychopharmacological aspects of smoking and smoking cessation in psychiatric patients. International Journal of Clinical and Pharmacological Therapy. 2002, 40 (9): 404-418.
Piasecki T, Baker T: Any further progress in smoking cessation treatment?. Nicotine & Tobacco Research. 2001, 3: 311-323. 10.1080/14622200110050484.
Covey L, Glassman A, Steiner F: Cigarette smoking and major depression. Journal of Addictive Disorders. 1998, 17 (1): 35-46. 10.1300/J069v17n01_04.
Ginsberg JP, Klesges RC, Johnson KC, Eck LH, Meyers AW, Winders SA: The relationship between a history of depression and adherence to a multicomponent smoking-cessation program. Addictive Behaviors. 1997, 22 (6): 783-787. 10.1016/S0306-4603(97)00018-X.
Kinnunen T, Doherty K, Militello FS, Garvey AJ: Depression and Smoking Cessation: Characteristics of Depressed Smokers and Effects of Nicotine Replacement. Journal of Consulting and Clinical Psychology. 1996, 64 (4): 791-798. 10.1037/0022-006X.64.4.791.
Thorsteinsson HS, Gillin JC, Patten CA, Golshan S, Sutton LD, Drummond S: The effects of transdermal nicotine therapy for smoking cessation on depressive symptoms in patients with major depression. Neuropsychopharmacology. 2001, 24 (4): 350-358. 10.1016/S0893-133X(00)00217-7.
Garvey AJ, Kinnunen T, Nordstrom BL, Utman CH, Doherty K, Rosner B: Effects of nicotine gum dose by level of nicotine dependence. Nicotine & Tobacco Research. 2000, 2 (1): 53-63. 10.1080/14622200050011303.
Ossip-Klein D, Bigelow G, Parker S, Curry S, Hall S, Kirkland S: Classification and assessment of smoking behavior. Health Psychology. 1986, 5 (Suppl): 3-11. 10.1037/0278-6133.5.Suppl.3.
Radloff LS: The CES-D scale: A self-report depression scale for research in the general population. Applied Psychological Measurement. 1977, 1: 385-401. 10.1177/014662167700100306.
Zonderman AB, Costa PT, McCrae RR: Depression as a risk factor for cancer morbidity and mortality in a nationally representative sample. Journal of the American Medical Association. 1989, 262: 1191-1195. 10.1001/jama.262.9.1191.
Zich JM, Attkisson CC, Greenfield TK: Screening for depression in primary care clinics: the CES-D and the BDI. International Journal of Psychiatry Medicine. 1990, 20 (3): 259-277.
Perneger TV: What's wrong with Bonferroni adjustements?. BMJ. 1998, 316 (7139): 1236-1238.
Pomerleau O, Pomerleau C, Mehringer A, Snedecor S, Ninowski R, Sen A: Nicotine dependence, depression, and gender: Characterizing phenotypes based on withdrawal discomfort, response to smoking, and ability to abstain. Nicotine & Tobacco Research. 2005, 7 (1): 91-102. 10.1080/14622200412331328466.
Lerman C, Caporaso N, Main D, Audrain J, Boyd NR, Bowman ED: Depression and self-medication with nicotine: the modifying influence of the dopamine D4 receptor gene. Health Psychology. 1998, 17 (1): 56-62. 10.1037/0278-6133.17.1.56.
Etter JF: A self-administered questionnaire to measure cigarette withdrawal symptoms: the Cigarette Withdrawal Scale. Nicotine & Tobacco Research. 2005, 7 (1): 47-57. 10.1080/14622200412331328501.
Catley D, Harris KJ, Okuyemi KS, Mayo MS, Pankey E, Ahluwalia JS: The influence of smoking cessation among African Americans in a randomized trial of bupropion. Nicotine & Tobacco Research. 2005, 7 (6): 859-870. 10.1080/14622200500330118.
Hitsman B, Pingitore R, Spring B, Mahableshwarkar A, Mizes JS, Segraves KA: Antidepressant pharmacotherapy helps some cigarette smokers more than others. Journal of Consulting and Clinical Psychology. 1999, 67: 547-554. 10.1037/0022-006X.67.4.547.
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