REVIEW PAPER
Destructive effects of smoking on molecular and genetic factors of periodontal disease
 
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1
Department of Preventive Dentistry, Graduate School of Dentistry, Osaka University, Suita, Japan
2
Department of Preventive and Public Health Dentistry, Fukuoka Dental College, Sawara-ku, Japan
CORRESPONDING AUTHOR
Takashi Hanioka   

Department of Preventive and Public Health Dentistry, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan
Publication date: 2010-02-20
 
Tobacco Induced Diseases 2010;8(February):4
 
KEYWORDS
ABSTRACT
Many epidemiological evidences have proven the association between smoking and periodontal disease. The causality can be further established by linking findings of traditional epidemiological studies with the developments in molecular techniques that occurred in the last decade. The present article reviews recent studies that address the effect of smoking on molecular and genetic factors in periodontal disease. Most findings support the fact that tobacco smoking modulates destruction of the periodontium through different pathways: microcirculatory and host immune systems, connective tissue, and bone metabolism. Although smokers experience an increased burden of inflammatory responses to microbial challenges compared to non-smokers, understanding the association between smoking and periodontal diseases involves substantial problems with respect to accuracy of measurements, and particularly, sampling of many subjects. It remains unclear whether genetic susceptibility to periodontal disease is influenced by exposure to smoking or the effect of smoking on periodontal disease is influenced by genetic susceptibility. Employment of molecular techniques may play a key role in further elucidation of mechanisms linking smoking and periodontal destruction, the direct relationship as environmental factors and indirect relationship through genetic factors.
 
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Takashi Hanioka, Manabu Morita, Tatsuo Yamamoto, Koji Inagaki, Pao-Li Wang, Hiroshi Ito, Toshiya Morozumi, Toru Takeshita, Nao Suzuki, Hideo Shigeishi, Masaru Sugiyama, Kouji Ohta, Toru Nagao, Nobuhiro Hanada, Miki Ojima, Hiroshi Ogawa
Japanese Dental Science Review
 
31.
Predicting doxorubicin drug delivery by single-walled carbon nanotube through cell membrane in the absence and presence of nicotine molecules: a molecular dynamics simulation study
Majid Pakdel, Heidar Raissi, Mahnaz Shahabi
Journal of Biomolecular Structure and Dynamics
 
32.
Orofacial infection and influencing factors on prolonged hospital stay: A four year retrospective study of 207 cases
Ching Yew, Mee Ng, Xiao Ling, Mei Tew
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
 
33.
Tracking Dental Patient Tobacco Use and Intervention in the Academic Clinical Setting
Susan Morgan, William Dumire, Carol Caudill, Amy Lewis
Journal of Dental Education
 
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